Recombinant Human Kras G12R, GST-Tag, GppNHp Loaded

(For Research Use Only)

Availability: In stock

Catalog #	Amount	Price	Tiered Pricing	Qty
5727-4128G-GP-100	100ug	$599.00
5727-4128G-GP-50	50ug	$399.00

Please inquire about custom configurations or bulk packaging.

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Kras is a member of the RAS protein family, which are a class of small GTPases involved in cell signaling. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner. As an oncogene mutated in several different cancers, the G12R substitution mutation favors the activated, GTP-bound state of the protein.

Recombinant Human Kras G12R, GST-Tag, GppNHp Loaded

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Scientific Details

Bioactivity:

Bioactivity please see document file

Formulation:

20 mM HEPES pH 7.5, 50 mM NaCl, 10 mM MgCl, 1 mM DTT, 10% glycerol

Purification:

N-GST Tagged, GppNHp Loaded

Purity:

>95% by SDS-PAGE

Source:

E. Coli

Storage & Stability:

Stable for 12 months at -80°C, Avoid freeze/thaw cycles

size:

50ug, 100ug

Suggested Usage:

Inhibitor Screening, binding assays, enzyme kinetics, and selectivity profiling.

Molecular Weight:

46.11 kDa + GppNHp

View / Download Product Data Sheets

Documentation:

GST-Kras-G12R-GppNHp_info.pdf

Catalog #	Product Name
5727-4122G	Recombinant Human Kras(G12C), Gst-Tag
5727-4122G-G	Recombinant Human Kras (G12C), GST-Tag, GDP Loaded
5727-WTG-GP	Recombinant Human Kras Wild-Type (WT), GST-Tag, GppNHp Loaded
5727-4128G	Recombinant Human Kras(G12V), Gst-Tag
5727-4122G-GP	Recombinant Human Kras G12C, GST-Tag, GppNHp Loaded
5727-4123G	Recombinant Human Kras(G12D), Gst-Tag
5727-4123G-G	Recombinant Human Kras (G12D), GST-Tag, GDP Loaded
5727-WTG-G	Recombinant Human Kras Wild-Type (WT), GST-Tag, GDP Loaded
5727-4121G	Recombinant Human Kras Wild-Type (WT), GST-Tag
5727-4123G-GP	Recombinant Human Kras G12D, GST-Tag, GppNHp Loaded
5727-4127G	Recombinant Human Kras(G12R), Gst-Tag
5727-4128G-G	Recombinant Human Kras (G12V), GST-Tag, GDP Loaded

References

1. Roman C. Hillig, et al. PNAS. 2019, vol. 116, no. 7, 2551–2560

2. Kari Kopra, et al. Anal. Chem. 2020, 92, 4971−4979

3. Fernández-Medarde A., et al. Genes (Basel). 2021;12(5):681.

Recombinant Human Kras G12R, GST-Tag, GppNHp Loaded

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Scientific Details

View / Download Product Data Sheets

References

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