Recombinant Human Kras (G13D), GST-Tag

(For Research Use Only)

Availability: In stock

Catalog # Amount Price Tiered Pricing Qty
5727-4133G-50
$369.00
5727-4133G-100
$559.00
Please inquire about custom configurations or bulk packaging.
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    Kras is a member of the RAS protein family, which are a class of small GTPases involved in cell signaling. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner.

    Recombinant Human Kras (G13D), GST-Tag

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    Scientific Details

    Bioactivity:
    Bioactivity please see document file
    Formulation:
    20 mM HEPES, 50 mM NaCl, 10 mM MgCl2, 1 mM DTT, 10% glycerol, pH 7.5
    Purification:
    N-GST Tagged
    Purity:
    >95% by SDS-PAGE
    Source:
    E. Coli
    Storage & Stability:
    Stable for 12 months at -80°C, Avoid freeze/thaw cycles
    Suggested Usage:
    Inhibitor Screening, binding assays, enzyme kinetics, GDP/GTP nucleotide exchange reaction

    View / Download Product Data Sheets

    Documentation:

    References

    1. Roman C. Hillig, et al.  PNAS. 2019, vol. 116, no. 7, 2551–2560

    2. Kari Kopra, et al.  Anal. Chem. 2020, 92, 4971−4979

    3. Fernández-Medarde A., et al. Genes (Basel). 2021;12(5):681.