Recombinant Human DNA polymerase theta (POLQ) N-terminal Helicase Domain

The Helicase Domain, is a functional domain within the POLQ enzyme that possesses helicase activity. Helicases are enzymes that play a crucial role in DNA replication and repair processes by unwinding double-stranded DNA.

The POLQ enzyme, with its N-terminal helicase domain, is involved in DNA repair pathways, particularly in repairing double-strand breaks (DSBs) in the DNA molecule. DSBs are severe DNA lesions that can occur due to various factors such as exposure to radiation or chemical agents. POLQ helps in the repair of DSBs through an alternative, error-prone DNA repair mechanism called alternative end-joining.