SARS-CoV-2, the viral agent responsible for the COVID-19 pandemic, is composed of an assortment of gene products critical to the viral lifecycle. We offer an assortment of SARS-CoV-2 recombinant proteins, kits, and services to advance your research and drug discovery needs.

SARS-CoV-2 Main/3CL Protease

SARS-CoV-2 Mpro Assay Kit

Recombinant SARS-CoV-2 Papain-like Protease

SARS-CoV-2 PLpro Assay Kit

Recombinant SARS-CoV-2 Helicase

Recombinant SARS-CoV-2 NSP7

Recombinant SARS-CoV-2 NSP8

SARS-CoV-2 Protease assays:

Our protease activity assays for our kits/service are FRET based assays. The assay kits are designed to detect the cleavage of peptide substrates specific for the protease of interest, either Mpro or PLpro, and is designed for inhibitor screening applications. In general, the assay is fast and convenient, and requires just two steps. In the first step, the protease enzyme is preincubated with inhibitor for 30 minutes. The reaction is initiated by adding protease substrate at the second step. Fluorescence intensity is measured with a fluorescent plate reader at the excitation wavelengths of 340-360 nm and emission wavelengths of 460-480 nm.