Anti-CD47 antibody
Anti-CD47 (magrolimab biosimilar;IgG1) mAb
CD47 is a transmembrane glycoprotein that plays a crucial role in immune regulation. It interacts with Signal-Regulatory Protein Alpha (SIRPα) on macrophages, delivering a "don't eat me" signal that prevents phagocytosis of healthy cells. This mechanism is exploited by cancer cells, which overexpress CD47 to evade immune destruction. Beyond immune evasion, CD47 is involved in cell adhesion, migration, and apoptosis, making it a key player in various physiological and pathological processes. Researchers are actively exploring anti-CD47 therapies to enhance immune responses against tumors.
