PTPRS is a member of a subfamily of receptor type PTPases that is characterized by the presence of an extracellular cell adhesion molecule-like motif and 2 intracellular phosphatase domains. The extracellular region of this protein is composed of multiple Ig-like and fibronectin type III-like domains. Studies of the similar gene in mice suggested that this PTP may be involved in cell-cell interaction, primary axonogenesis, and axon guidance during embryogenesis.
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