WEE1 is a nuclear protein kinase that regulates G2/M transition in response to DNA damage. It catalyzes an inhibitory tyrosine phosphorylation of cyclin-dependent kinase 1-bound cyclin B resulting in G2 cell cycle arrest. WEE1 also maintains the proper timing of cell division through phosphorylation of tyrosine15 residues of cyclin-dependent kinases 1 and 2, thereby modulating the activity of both kinases and controlling entry into mitosis and DNA replication during S phase.
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