The human CD70 extracellular domain(s), consisting of amino acids 39-193, with an IgG-Fc tag linked to a N-terminal 10x-histidine sequence. The CD70 protein is a transmembrane receptor that is involved in regulating cell growth, differentiation, and survival. It is primarily found on the surface of T cells, B cells, and natural killer cells. The CD70 receptor binds with its ligand, CD27, leading to downstream signaling pathways that activate T cells and promote immune responses. Dysregulation of this pathway has been implicated in various diseases, including cancer, autoimmune disorders, and infectious diseases. Therefore, CD70 has become a target for therapeutic interventions, including antibody-based therapies and immune checkpoint inhibitors.

CD70 Information