The human OX40 extracellular domains, consisting of amino acids 1-216, with a Avi tag linked to a C-terminal 10x-histidine sequence. OX40 (CD134) is a protein receptor that is expressed on the surface of activated T cells. It plays a crucial role in the regulation of immune responses through its interaction with its ligand, OX40L. This interaction leads to the activation of various signaling pathways, resulting in enhanced T cell proliferation, survival, and cytokine production. Therefore, OX40 has been considered as a promising target for cancer immunotherapy and autoimmune diseases due to its ability to enhance immune responses against tumors or diseased cells while also limiting excessive inflammation. Several monoclonal antibodies targeting OX40 are currently being developed as potential therapeutics.

OX40 Information