Cyclophilin A (CypA) is a cytosolic peptidyl-prolyl cis-trans isomerase (PPIase) that plays a pivotal role in protein folding, intracellular trafficking, and signaling. It is widely recognized for its high-affinity binding to the immunosuppressive drug cyclosporin A and its regulatory influence on immune responses. Emerging evidence also links CypA to the modulation of KRAS signaling pathways, making it a valuable target in cancer research. Recombinant CypA is available in high purity and is suitable for use in protein-protein interaction studies, enzymatic assays, and drug discovery, particularly in the context of oncogenic KRAS-driven cancers.

CypA/PPIA Information

CypA/PPIA MSDS