Helicases are motor proteins that unwind a double-stranded (ds) nucleic acid into two single-stranded (ss) nucleic acids using energy derived from NTP. Helicase (Nsp13) of Severe acute respiratory Coronavirus 2 is the most conserved non-structural protein within the coronavirus family and is critical for viral replication. The functional relevance of helicases activities indicates that inhibition of helicase is potentially important for developing therapeutic agents.

SARS-CoV-2 Helicase NSP13 Information