Nsp8 is one cofactor of SARS-CoV-2 RNA polymerase complex and can remarkably improve RdRp polymerase activity. The viral polymerase is essential for the coronavirus replication. With the high evolutionary stability compared with surface proteins, SARS-CoV-2 RNA polymerase has become a major target of antiviral drugs.

SARS-CoV-2 NSP8 Information