SARS-CoV-2 Papain like protease (PLpro) is one of the viral proteases to process viral polypeptide to functional proteins, the process essential for viral transcription, replication and virion assembly. PLpro can deubiquitinate host cell proteins and inactivate the NF-κB pathway, resulting in the immune suppression of host cells. Due to its multiple roles in viral replication and host cell control, PLpro is considered a potential antiviral target.

PLpro NSP3 Information